尼日利亚人群中的鹰爪豆碱代谢

Sparteine metabolism in a Nigerian population.

作者信息

Ritchie J C, Mitchell S C, Smith R L

机构信息

Imperial College School of Medicine at St. Mary's, London, U.K.

出版信息

Drug Metabol Drug Interact. 1996;13(2):129-35. doi: 10.1515/dmdi.1996.13.2.129.

DOI:10.1515/dmdi.1996.13.2.129

PMID:8905244

Abstract

The oxidative metabolism of sparteine has been investigated in a Nigerian population. The distribution of metabolic capacities was shown to be skewed with two subjects (2/97, 2.1%) being relatively deficient in their ability to produce the dehydrometabolites. These observations afford evidence that sparteine oxidation is under polymorphic control in Nigerians.

摘要

在尼日利亚人群中对司巴丁的氧化代谢进行了研究。结果表明代谢能力的分布呈偏态，有两名受试者（2/97，2.1%）生成脱氢代谢产物的能力相对不足。这些观察结果为司巴丁氧化在尼日利亚人身上受多态性控制提供了证据。