Lowenkron S E, Waxner J, Khullar P, Ilowite J S, Niederman M S, Fein A M
Department of Medicine, State University of New York, USA.
Intensive Care Med. 1996 Sep;22(9):990-4. doi: 10.1007/BF02044130.
Although colitis is often seen in critically all patients who have received multiple broad-spectrum antibiotics, there are no reports describing severe sepsis as a result of Clostridium difficile infection. We describe three cases of severe sepsis with local intestinal Clostridium difficile infection as the only identifiable etiology. The mechanism of severe sepsis may be a derangement of the gastrointestinal barrier function. This could result in absorption of microbes or endotoxin or activation of inflammatory cascades in the submucosa of the intestine or liver.
尽管在接受多种广谱抗生素治疗的所有重症患者中常可见结肠炎，但尚无关于艰难梭菌感染导致严重脓毒症的报道。我们描述了3例严重脓毒症病例，其唯一可识别的病因是局部肠道艰难梭菌感染。严重脓毒症的机制可能是胃肠屏障功能紊乱。这可能导致微生物或内毒素吸收，或肠道或肝脏黏膜下层炎症级联反应激活。
