Lindgren U, Mattsson S
Calcif Tissue Res. 1977 Jun 28;23(2):179-84. doi: 10.1007/BF02012784.
One hind leg of 80 adult rats of the Sprague-Dawley strain was made osteoporotic by immobilization for 9 weeks. Osteoporosis was noted in both the femur and the tibia when the hydrated gross bone density and the bone surface areas were measured. No signs of reversibility were observed during 10 weeks after the period of immobilization. Tetracycline and DCAF labelling failed to show significant signs of increased bone formation during the 10 weeks after remobilization. At the moment of remobilization and for some weeks thereafter, there were signs of depressed mitotic activity in the bone cells when expressed as the 3H-thymidine/DNA ratio. The conclusion was that neither the cell-proliferation rate nor the cellular activity increases sufficiently for restitution of the disuse osteoporosis.
将80只成年斯普拉格-道利大鼠的一条后腿固定9周，使其发生骨质疏松。测量水合骨总密度和骨表面积时，发现股骨和胫骨均出现骨质疏松。在固定期后的10周内，未观察到可逆迹象。重新活动后的10周内，四环素和双氯芬酸标记未显示骨形成增加的明显迹象。重新活动时及之后的几周内，以3H-胸腺嘧啶核苷/DNA比值表示时，骨细胞有丝分裂活性降低的迹象。结论是，细胞增殖率和细胞活性均未充分增加以恢复废用性骨质疏松。
