Swank M W, Ellis A E, Cochran B N
Department of Psychology, Furman University, Greenville, SC 29613, USA.
Neuroreport. 1996 Jul 29;7(11):1866-70. doi: 10.1097/00001756-199607290-00036.
Conditioned taste aversion is an unusual form of associative learning in which long delays between conditional stimulus taste (CS) and unconditioned stimulus illness (US) suggest stimulus encoding by novel mechanisms. Recent data suggest that stimulus inputs are encoded by inducible bZIP proteins, the kinetics of which match the temporal features of the CS and US in taste aversion learning. Blockade of US-induced c-Fos translation in the brain stem by antisense oligonucleotides specifically blocks both acquisition and extinction of a learned taste aversion, but does not impair sensory processing of either CS or US, suggesting that c-Fos antisense blocks associative events within NTS necessary to support taste aversion learning.
条件性味觉厌恶是一种特殊形式的联想学习，其中条件刺激味觉（CS）和非条件刺激疾病（US）之间的长时间延迟表明其通过新机制进行刺激编码。最近的数据表明，刺激输入由可诱导的碱性亮氨酸拉链蛋白编码，其动力学与味觉厌恶学习中CS和US的时间特征相匹配。反义寡核苷酸对脑干中US诱导的c-Fos翻译的阻断特异性地阻断了习得性味觉厌恶的获得和消退，但不损害CS或US的感觉处理，这表明c-Fos反义阻断了孤束核内支持味觉厌恶学习所必需的联想事件。
