Jønsson B, Hauge B, Larsen M F, Hald F
Department of Obstetrics and Gynaecology, Kolding Hospital, Denmark.
Acta Obstet Gynecol Scand. 1996 Sep;75(8):725-9. doi: 10.3109/00016349609065735.
To investigate whether zinc supplementation during pregnancy improves maternal and fetal outcome.
Controlled clinical trial started at registration until discharge of mother and child from hospital. Two thousand volunteer mothers were randomly assigned to receive zinc supplementation or placebo in a double blind trial.
Women less than 20 weeks pregnant at the first visit who agreed to take part in the study. One thousand two hundred and six mothers were available for study.
Volunteers were randomly selected to receive two tablets of zinc (44 mg zinc in total) or two placebo tablets containing inert substances, indistinguishable in appearance and taste from the zinc tablets.
Large for gestational age (LGA), small for gestational age (SGA), premature rupture of the membrane (PROM), preterm labor (PL), preeclampsia and bleeding in the second or third trimester.
There were no differences between mothers given zinc supplementation concerning the outcome parameters and those given placebo.
Zinc supplementation in pregnancy in a normal healthy middle class population in Denmark does not seem to offer any benefits to the mother or her fetus.
研究孕期补充锌是否能改善母婴结局。
从登记开始至母婴出院的对照临床试验。两千名志愿母亲在双盲试验中被随机分配接受补锌或安慰剂。
首次就诊时孕周小于20周且同意参与研究的女性。1206名母亲可供研究。
志愿者被随机选择接受两片锌片（共含44毫克锌）或两片含惰性物质的安慰剂片，其外观和味道与锌片无法区分。
大于胎龄（LGA）、小于胎龄（SGA）、胎膜早破（PROM）、早产（PL）、子痫前期以及孕中期或孕晚期出血。
接受补锌的母亲与接受安慰剂的母亲在结局参数方面没有差异。
在丹麦正常健康的中产阶级人群中，孕期补锌似乎对母亲或其胎儿没有任何益处。
