Nasri S, Newman J P, Goode R L, Koch R J
Division of Otolaryngology-Head and Neck Surgery, Stanford University Medical Center, Calif, USA.
Arch Otolaryngol Head Neck Surg. 1996 Nov;122(11):1169-73. doi: 10.1001/archotol.1996.01890230017004.
To compare the effect of superpulsed carbon dioxide (CO2) laser alone with that of cryotherapy in combination with CO2 laser in treatment of facial rhytids.
A randomized prospective study.
Facial Plastic Surgery Clinic at Standford University Medical Center, Standford, Calif.
Twenty patients with perioral rhytids were randomized in the study, 11 in the laser group and 9 in the cryotherapy and laser group.
Patients in the laser group were treated with superpulsed CO2 laser. Initially, the shoulders of rhytids were spot treated. The area was then wiped and rehydrated. The entire surface was then treated with a second pass. A third pass, if deemed necessary, was then used to treat the shoulders. Patients in the combined group underwent cryotherapy of the entire perioral region followed by CO2 laser treatment similar to that previously described.
Improvement in facial rhytids with laser treatment alone was compared with improvement using cryotherapy and laser. A skin wrinkle grading system was used and patients were graded by 3 independent observers. Close-up photographs were obtained preoperatively and postoperatively. A questionnaire was filled out by each patient 1 month following treatment and was used to rate overall patient satisfaction.
There was no statistically significant difference between the 2 groups regarding final outcome, amount of anesthetic agents required for each patient, or rate of complications.
Superpulsed CO2 skin resurfacing alone is as effective as combined cryotherapy and superpulsed CO2 laser for treatment of perioral rhytids.
比较单纯超脉冲二氧化碳（CO₂）激光与冷冻疗法联合CO₂激光治疗面部皱纹的效果。
一项随机前瞻性研究。
加利福尼亚州斯坦福市斯坦福大学医学中心面部整形手术诊所。
20例口周皱纹患者被随机纳入本研究，激光组11例，冷冻疗法联合激光组9例。
激光组患者接受超脉冲CO₂激光治疗。最初，对皱纹的肩部进行点状治疗。然后擦拭该区域并补充水分。接着对整个表面进行第二次治疗。如有必要，第三次治疗用于处理肩部。联合组患者先对口周整个区域进行冷冻疗法，然后进行与上述类似的CO₂激光治疗。
比较单纯激光治疗与冷冻疗法联合激光治疗面部皱纹的改善情况。采用皮肤皱纹分级系统，由3名独立观察者对患者进行分级。术前和术后均拍摄特写照片。每位患者在治疗后1个月填写一份问卷，用于评估患者的总体满意度。
两组在最终结局、每位患者所需麻醉剂用量或并发症发生率方面无统计学显著差异。
单纯超脉冲CO₂皮肤磨削术在治疗口周皱纹方面与冷冻疗法联合超脉冲CO₂激光同样有效。
