一只维兹拉犬播散性拟青霉病的诊断、治疗及暂时缓解

Diagnosis, treatment, and temporary remission of disseminated paecilomycosis in a vizsla.

作者信息

March P A, Knowles K, Dillavou C L, Jakowski R, Freden G

机构信息

Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA.

出版信息

J Am Anim Hosp Assoc. 1996 Nov-Dec;32(6):509-14. doi: 10.5326/15473317-32-6-509.

DOI:10.5326/15473317-32-6-509

PMID:8906728

Abstract

A case of disseminated paecilomycosis in a three-year-old vizsla is described. Clinical signs of lethargy, weight loss, lymphadenopathy, diarrhea, and vestibulocochlear deficits were exhibited. Dense colonization of bone marrow by the fungus was found early in the disease course. Serial culture of bone-marrow aspirates and in vitro sensitivity testing helped monitor disease progression and guide antifungal therapy. Clinical and laboratory parameters demonstrated marked improvement for a period of 12 weeks. Multisystemic disease with central nervous system involvement was found at necropsy.

摘要

本文描述了一例3岁维兹拉犬的播散性拟青霉病病例。该犬表现出嗜睡、体重减轻、淋巴结病、腹泻和前庭蜗神经功能缺损等临床症状。在病程早期发现骨髓被该真菌大量定植。对骨髓穿刺液进行连续培养和体外药敏试验有助于监测疾病进展并指导抗真菌治疗。临床和实验室参数显示在12周内有显著改善。尸检发现有多系统疾病并累及中枢神经系统。