尿中1-羟基芘，铸造工人的一种多环芳烃生物标志物。
Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers.
作者信息
Omland O, Sherson D, Hansen A M, Sigsgaard T, Autrup H, Overgaard E
机构信息
Department of Occupational Medicine, Aarhus University Hospital, Denmark.
出版信息
Cancer Detect Prev. 1996;20(1):57-62.
Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p < 0.001, r2 = 0.69. Only foundry work (p < 0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.
通过反相高效液相色谱法定量测定尿中1-羟基芘（HPU）水平，对铸造工人接触多环芳烃（PAH）的情况进行了研究。对70名男性铸造工人和68名匹配的对照组进行了调查。多环芳烃（PAH）暴露由17个呼吸带卫生样本定义，这些样本由16种选定的PAH化合物组成。PAH总平均浓度（标准差）为10.40（4.04）μg/m³。烟草消费量、年龄、空气中PAH暴露和铸造工作对log HPU的多元回归模型显示出显著相关性，p < 0.001，r² = 0.69。只有铸造工作（p < 0.0001）和空气中PAH暴露（p = 0.0478）对该模型有显著贡献。这些数据表明，HPU是低剂量PAH暴露的敏感生物标志物。
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