Lawrie G A, Schneider P B, Battersby B J, Barnes G T, Cammenga H K
Department of Chemistry, The University of Queensland, St. Lucia, Australia.
Chem Phys Lipids. 1996 Jan 25;79(1):1-8. doi: 10.1016/0009-3084(95)02500-6.
The spreading behavior of bulk lipid crystals and lipid dispersed in water has been investigated for dimyristoyl phosphatidylcholine at the air/water interface. The stable surface pressures reached with dispersed lipid were found to increase with lipid concentration up to a concentration of approximately 1.2 mg ml-1 where the spreading pressure approached 45 mN m-1, the value for excess lipid crystals placed on the surface (at 30.5 degrees C). These low surface pressures obtained with dispersions are attributed to the existence of 'pre-equilibria': surface pressures that appear steady because of the extremely slow approach to final equilibrium. Attainment of this pre-equilibrium condition usually takes about 20 h, whereas bulk crystals held at the surface generated a high and steady surface pressure within about 1 h. Hydration of the bulk lipid slows down the spreading rate, but does not affect the final surface pressure.
已针对二肉豆蔻酰磷脂酰胆碱在空气/水界面研究了块状脂质晶体和分散在水中的脂质的铺展行为。发现分散脂质达到的稳定表面压力随脂质浓度增加，直至浓度约为1.2 mg/ml，此时铺展压力接近45 mN/m，这是放置在表面的过量脂质晶体的值（在30.5摄氏度下）。分散体获得的这些低表面压力归因于“预平衡”的存在：由于达到最终平衡的过程极其缓慢，表面压力看起来稳定。达到这种预平衡状态通常需要约20小时，而置于表面的块状晶体在约1小时内产生高且稳定的表面压力。块状脂质的水合作用会减慢铺展速率，但不影响最终表面压力。
