Costa Rosa L F, Safi D A, Cury Y, Curi R
Cellular Physiology Group, Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, Brazil.
Cell Biochem Funct. 1996 Mar;14(1):33-42. doi: 10.1002/cbf.637.
This study examined the effect of insulin on rat macrophage metabolism and function. The following parameters were studied: cell migration in response to thioglycollate and BCG stimuli, macrophage phagocytic capacity, H2O2 production, glucose and glutamine metabolism as indicated by the measurement of enzyme activities, the utilization of metabolites and production and oxidation of substrates. The results indicate that insulin: (1) did not affect cell migration in response to thioglycollate and BCG; (2) enhanced the phagocytic capacity of macrophages and the production of H2O2 by macrophages; (3) increased the metabolism of glucose and reduced that of glutaminase.
本研究检测了胰岛素对大鼠巨噬细胞代谢及功能的影响。研究了以下参数：对巯基乙酸盐和卡介苗刺激的细胞迁移、巨噬细胞吞噬能力、过氧化氢生成、通过酶活性测定、代谢物利用以及底物生成和氧化所表明的葡萄糖和谷氨酰胺代谢。结果表明，胰岛素：（1）不影响对巯基乙酸盐和卡介苗的细胞迁移；（2）增强巨噬细胞的吞噬能力以及巨噬细胞的过氧化氢生成；（3）增加葡萄糖代谢并降低谷氨酰胺酶的代谢。
