Slavutsky I, Andreoli G, Gutierrez M, Narbaitz M, Lucero G, Eppinger M
Departmento de Genetica, Academia Nacional de Medicina, Buenos Aires, Argentina.
Leuk Lymphoma. 1996 Mar;21(1-2):169-72. doi: 10.3109/10428199609067595.
Occasional cases with the chromosomal translocations that juxtapose the c-myc oncogene to Ig genes have been reported in large cell, small lymphocytic, immunoblastic, and follicular lymphomas. In this report, we present a 20 year-old female with lymphoblastic lymphoma of B-cell type and a translocation t(8;22), in which cytogenetic, immunologic, and molecular studies were performed. To the best of our knowledge this is the first report of this association.
在大细胞、小淋巴细胞、免疫母细胞和滤泡性淋巴瘤中,偶有关于c-myc癌基因与Ig基因并列的染色体易位病例的报道。在本报告中,我们介绍了一名20岁的B细胞型淋巴母细胞淋巴瘤女性患者,其存在t(8;22)易位,并对其进行了细胞遗传学、免疫学和分子学研究。据我们所知,这是这种关联的首次报告。