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淋巴细胞淋巴瘤中的(8;22)易位变异型

Variant (8;22) translocation in lymphoblastic lymphoma.

作者信息

Slavutsky I, Andreoli G, Gutierrez M, Narbaitz M, Lucero G, Eppinger M

机构信息

Departmento de Genetica, Academia Nacional de Medicina, Buenos Aires, Argentina.

出版信息

Leuk Lymphoma. 1996 Mar;21(1-2):169-72. doi: 10.3109/10428199609067595.

Abstract

Occasional cases with the chromosomal translocations that juxtapose the c-myc oncogene to Ig genes have been reported in large cell, small lymphocytic, immunoblastic, and follicular lymphomas. In this report, we present a 20 year-old female with lymphoblastic lymphoma of B-cell type and a translocation t(8;22), in which cytogenetic, immunologic, and molecular studies were performed. To the best of our knowledge this is the first report of this association.

摘要

在大细胞、小淋巴细胞、免疫母细胞和滤泡性淋巴瘤中,偶有关于c-myc癌基因与Ig基因并列的染色体易位病例的报道。在本报告中,我们介绍了一名20岁的B细胞型淋巴母细胞淋巴瘤女性患者,其存在t(8;22)易位,并对其进行了细胞遗传学、免疫学和分子学研究。据我们所知,这是这种关联的首次报告。

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