Malerbi D A, Paiva E S, Duarte A L, Wajchenberg B L
Endocrine and Nutrition Services, Hospital das Clínicas, University of Säo Paulo Medical School, Brazil.
Diabetes Care. 1996 Nov;19(11):1249-56. doi: 10.2337/diacare.19.11.1249.
To investigate the metabolic effects of dietary fructose and sucrose in type II diabetic patients.
Sixteen well-controlled type II diabetic subjects were fed three isocaloric diets for 28 days each. The three diets provided 50-55, 15, and 30-35% of total energy from carbohydrate, protein, and fat, respectively. In one diet, 20% of total calories were derived from fructose; in another, 19% of total calories were derived from sucrose; and in the control diet, only 5% of daily calories were derived from sugars, all other carbohydrates being supplied as polysaccharides.
No significant differences were observed between either the fructose or the sucrose diet and the control polysaccharide diet in any of the measures of glycemic control, serum lipid levels, or insulin and C-peptide secretion.
Our data suggest that in the short and middle terms, high fructose and sucrose diets do not adversely affect glycemia, lipemia, or insulin and C-peptide secretion in well-controlled type II diabetic subjects.
研究膳食果糖和蔗糖对II型糖尿病患者的代谢影响。
16名病情控制良好的II型糖尿病受试者，每人分别食用三种等热量饮食，为期28天。三种饮食分别提供碳水化合物、蛋白质和脂肪占总能量的50 - 55%、15%和30 - 35%。在一种饮食中，20%的总热量来自果糖；在另一种饮食中，19%的总热量来自蔗糖；在对照饮食中，每日仅5%的热量来自糖类，所有其他碳水化合物均以多糖形式提供。
在血糖控制、血脂水平或胰岛素及C肽分泌的任何指标上，果糖饮食或蔗糖饮食与对照多糖饮食之间均未观察到显著差异。
我们的数据表明，在短期和中期，高果糖和高蔗糖饮食对病情控制良好的II型糖尿病受试者的血糖、血脂、胰岛素及C肽分泌无不良影响。
