Department of Applied Sciences, Northumbria University, Ellison Building, Newcastle-Upon-Tyne NE3 7ST, UK.
J Nutr Sci. 2021 Aug 11;10:e60. doi: 10.1017/jns.2021.55. eCollection 2021.
Epidemiological and intervention studies have reported negative health effects of sucrose intake, but many of these studies were not representative of typical dietary habits. In this pilot study, we aimed to test the effect of increasing sucrose intakes for 1 week on body composition and blood pressure and explore the feasibility of consuming high intakes of sucrose in addition to a habitual diet. In a randomised crossover design study, twelve healthy participants (50 % female, age 28⋅4 ± 10 years, BMI 25 ± 3 kg/m), consumed either 40, 80 or 120 g sucrose in 500 ml water in addition to their habitual diet every day for 1 week, with a 1-week washout between treatment periods. Body composition (assessed using bioelectrical impedance) and blood pressure measurements were taken before and after each intervention phase. All participants reported no issues with consuming the sucrose dose for the intervention period. There was a significant increase in systolic blood pressure following 120 g sucrose intake ( = 0⋅006), however there was no significant changes to blood pressure, body weight, BMI, percentage protein, fat or water ( > 0⋅05) when comparing change from baseline values. There was also no effect of sucrose intakes on energy or macronutrient intakes during the intervention ( > 0⋅05). We show here that varying doses of sucrose over a 1-week period have no effect on body composition or blood pressure. The amounts of sucrose used were an acceptable addition to the habitual diet and demonstrate the feasibility of larger-scale studies of chronic sucrose supplementation.
流行病学和干预研究报告了蔗糖摄入对健康的负面影响,但其中许多研究并不能代表典型的饮食习惯。在这项初步研究中,我们旨在测试在一周内增加蔗糖摄入量对身体成分和血压的影响,并探讨在习惯饮食之外摄入高剂量蔗糖的可行性。在一项随机交叉设计研究中,十二名健康参与者(女性占 50%,年龄 28.4±10 岁,BMI 25±3kg/m²),每天在习惯饮食之外,分别额外摄入 40、80 或 120 克蔗糖溶于 500 毫升水中,每种剂量干预持续一周,每种剂量干预之间有一周洗脱期。在每个干预阶段前后,都使用生物电阻抗法测量身体成分和血压。所有参与者均报告在干预期间摄入蔗糖剂量没有问题。120 克蔗糖摄入后收缩压显著升高(=0.006),但与基线值相比,血压、体重、BMI、蛋白质百分比、脂肪或水均无显著变化(>0.05)。蔗糖摄入量对干预期间的能量或宏量营养素摄入量也没有影响(>0.05)。我们在此表明,在一周内摄入不同剂量的蔗糖对身体成分或血压没有影响。所使用的蔗糖量可以作为习惯饮食的可接受补充,并且证明了更大规模慢性蔗糖补充研究的可行性。