Hillen M E, Sage J I
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903, USA.
Neurology. 1996 Nov;47(5):1180-3. doi: 10.1212/wnl.47.5.1180.
We studied the nature and frequency of nonmotor "off" phenomena in 130 consecutive patients with Parkinson's disease (PD) with motor fluctuations. Twenty-two patients (17%) experienced nonmotor fluctuations as an end-of-dose phenomenon. Previously unreported, or little appreciated, nonmotor "off" states include sensory dyspnea, nausea, facial flushing, cough, hunger, unilateral limb edema, proximal limb pain, and trigeminal neuralgia-like pain. We attempted treatment modification in 12 of 22 patients; nonmotor "off" symptoms improved in nine of these 12 patients (75%). Recognizing these phenomena will prevent unnecessary tests and treatments.
我们研究了130例连续的伴有运动波动的帕金森病（PD）患者非运动“关”现象的性质和频率。22例患者（17%）经历了非运动波动作为剂末现象。以前未报告或很少被认识到的非运动“关”状态包括感觉性呼吸困难、恶心、面部潮红、咳嗽、饥饿、单侧肢体水肿、近端肢体疼痛和三叉神经痛样疼痛。我们对22例患者中的12例尝试了调整治疗；这12例患者中有9例（75%）非运动“关”症状得到改善。认识到这些现象将避免不必要的检查和治疗。
