Antony S J, Stratton C W, Dummer J S
Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Clin Infect Dis. 1996 Oct;23(4):773-8. doi: 10.1093/clinids/23.4.773.
Lactobacillus bacteremia in the absence of endocarditis is a rare entity, and the clinical relevance of such bacteremia remains unclear. The clinical courses of lactobacillus bacteremia without endocarditis in 43 previously described patients and 12 new patients were reviewed. Bacteremia with Lactobacillus alone occurred in 34 (62%) of the patients, and 12 (22%) of the patients had bacteremia with other organisms, including Lactobacillus. Lactobacillus was isolated from another site in 18 (33%) of these patients. Intravenous catheter infections were not noted in these patients. Underlying conditions included cancer (6 patients), organ transplantation (9), diabetes mellitus (4), and recent surgery (12). Fever occurred in all patients, and eight (15%) of the patients experienced a sepsis syndrome. The mortality rate was 14%; however, only three deaths were attributed soley to lactobacillus sepsis. Lactobacillus bacteremia is an uncommon condition that usually occurs in patients with severe underlying illnesses and is frequently seen as a part of a polymicrobial infection. Blood cultures positive for Lactobacillus represent true infection and not contamination. Although resistance to commonly used antibiotics is common, the mortality rate associated with this bacteremia appears to be low.
无感染性心内膜炎的乳酸杆菌血症是一种罕见病症，此类菌血症的临床相关性仍不明确。回顾了43例既往报道患者及12例新患者无感染性心内膜炎的乳酸杆菌血症的临床病程。仅乳酸杆菌引起的菌血症发生于34例（62%）患者，12例（22%）患者的菌血症由包括乳酸杆菌在内的其他微生物引起。这些患者中有18例（33%）在其他部位分离出乳酸杆菌。这些患者未发现静脉导管感染。基础疾病包括癌症（6例）、器官移植（9例）、糖尿病（4例）和近期手术（12例）。所有患者均发热，8例（15%）患者出现脓毒症综合征。死亡率为14%；然而，仅3例死亡完全归因于乳酸杆菌败血症。乳酸杆菌血症是一种不常见的病症，通常发生于有严重基础疾病的患者，且常作为多微生物感染的一部分出现。乳酸杆菌血培养阳性代表真正感染而非污染。虽然对常用抗生素耐药很常见，但与此类菌血症相关的死亡率似乎较低。
