Mikucka Agnieszka, Deptuła Aleksander, Bogiel Tomasz, Chmielarczyk Agnieszka, Nurczyńska Elżbieta, Gospodarek-Komkowska Eugenia
Department of Microbiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
Department of Propaedeutics of Medicine and Infection Prevention, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
Pathogens. 2022 Aug 26;11(9):977. doi: 10.3390/pathogens11090977.
Lactic acid bacteria belonging to spp. and spp. are a natural part of fermented milk and other food products, probiotic supplements and human microbiota. They mainly belong to mucosal microflora, especially oral, vaginal and intestinal. spp. strains included in probiotics are generally characterised as safe microorganisms, and the species are concerned bacteria with very low pathogenic potential. However, infections caused by spp. and spp., including bacteraemia and endocarditis, occur occasionally. The aim of the study was to present two cases of bacteraemia due to associated with the use of a probiotic product. It afflicted patients in intensive care units. The investigation was preliminarily based on clinical and microbiological recognition of the cases. The initial observation was laboratory confirmed with the application of pulsed-field gel electrophoresis (PFGE) results. Identical PFGE patterns were obtained for the evaluated strains and the strains derived from a commercially available probiotic that was administered to those patients. The increasing number of studies describing opportunistic infections due to probiotic strains of spp. should result in verifying the safety of probiotic formulations used in immunocompromised patients and forming detailed guidelines for the use of probiotics among patients from several risk groups.
属于 属和 属的乳酸菌是发酵乳及其他食品、益生菌补充剂和人类微生物群的天然组成部分。它们主要属于黏膜微生物群，尤其是口腔、阴道和肠道的微生物群。益生菌中包含的 属菌株通常被表征为安全微生物，该属细菌的致病潜力非常低。然而，由 属和 属引起的感染，包括菌血症和心内膜炎，偶尔会发生。本研究的目的是介绍两例因使用益生菌产品而导致的 菌血症病例。患者均在重症监护病房。调查初步基于对病例的临床和微生物学识别。通过应用脉冲场凝胶电泳（PFGE）结果对初步观察进行了实验室确认。评估菌株与给予这些患者的市售益生菌衍生的菌株获得了相同的PFGE图谱。越来越多关于 属益生菌菌株引起机会性感染的研究应促使对免疫功能低下患者使用的益生菌制剂的安全性进行验证，并为几个风险组的患者制定详细的益生菌使用指南。
