Fowler E B, Cuenin M F, Thompson S H, Kudryk V L, Billman M A
Periodontics Department, U.S. Army Dental Activity, Ft. Gordon, GA, USA.
J Periodontol. 1996 Oct;67(10):1011-5. doi: 10.1902/jop.1996.67.10.1011.
A pyogenic granuloma is an exuberant growth of granulation tissue secondary to irritation. Intraorally, it can present with a wide array of clinical appearances, ranging from a sessile lesion to an elevated mass. Pyogenic granulomas generally are soft, painless, and deep red to reddish-purple in color. They are usually 0.5 to 1.0 cm in diameter, more common in females, and often found on the keratinized tissue. This case is interesting because the pyogenic granuloma was found associated with guided tissue regeneration and the lingual alveolar mucosa. The lesion arose after demineralized freeze dried bone allograft and an expanded polytetrafluoroethylene (ePTFE) membrane were utilized to repair osseous defects. Five weeks after surgery, the patient presented for routine follow-up where suppuration associated with the membrane was noted along with an exophytic growth of the lingual alveolar mucosa. The ePTFE membrane was removed alone with an excisional biopsy of one of the growths. By 10 days after the removal of ePTFE, the lesion spontaneously healed. Histologic evaluation of the tissue was consistent with a pyogenic granuloma. This is the first case in the literature of a pyogenic granuloma associated with a routine guided tissue regenerative surgery using a non-resorbable membrane and allograft.
化脓性肉芽肿是继发于刺激后的肉芽组织过度生长。在口腔内，它可呈现出多种临床表现，从扁平状病变到隆起肿物不等。化脓性肉芽肿通常质地柔软、无痛，颜色从深红色到红紫色。它们直径通常为0.5至1.0厘米，在女性中更常见，且常出现在角化组织上。该病例有趣之处在于化脓性肉芽肿与引导组织再生及舌侧牙槽黏膜相关。病变在使用脱矿冻干骨同种异体移植物和膨体聚四氟乙烯（ePTFE）膜修复骨缺损后出现。术后五周，患者前来进行常规随访，发现与膜相关的化脓以及舌侧牙槽黏膜的外生性生长。单独移除ePTFE膜并对其中一个增生组织进行切除活检。在移除ePTFE膜后10天，病变自发愈合。组织的组织学评估与化脓性肉芽肿一致。这是文献中首例与使用不可吸收膜和同种异体移植物的常规引导组织再生手术相关的化脓性肉芽肿病例。
