Hsieh M T, Wu L Y
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, Republic of China.
J Pharm Pharmacol. 1996 Sep;48(9):959-61. doi: 10.1111/j.2042-7158.1996.tb06011.x.
The effects of (+/-)-tetrahydropalmatine ((+/-)-THP) on the hypothalamus-pituitary-thyroid system in rats were investigated. Thyroid function experiments indicated that (+/-)-THP produces significant decreases in thyroid function in hyperthyroid rats after 14 days of treatment. These effects were the same as those of propylthiouracil. However, propylthiouracil also decreased thyroid function in normal rats. Measurements of thyrotropin-stimulating hormone (TSH) demonstrated that (+/-)-THP decreased TSH in hyperthyroid rats after 14 days of treatment; however, propylthiouracil increased TSH in hyperthyroid rats. (+/-)-THP had no influence on TSH, or thyroid and pituitary weight in normal and hyperthyroid rats. We conclude that (+/-)-THP has an antithyroid function and the mechanism of action may be related to the inhibition of TSH in the pituitary.
研究了(±)-四氢巴马汀((±)-THP)对大鼠下丘脑-垂体-甲状腺系统的影响。甲状腺功能实验表明，(±)-THP在治疗14天后可使甲亢大鼠的甲状腺功能显著降低。这些作用与丙硫氧嘧啶相同。然而，丙硫氧嘧啶也会降低正常大鼠的甲状腺功能。促甲状腺激素(TSH)测量结果显示，(±)-THP在治疗14天后可使甲亢大鼠的TSH降低；然而，丙硫氧嘧啶可使甲亢大鼠的TSH升高。(±)-THP对正常和甲亢大鼠的TSH、甲状腺及垂体重量均无影响。我们得出结论，(±)-THP具有抗甲状腺功能，其作用机制可能与抑制垂体中的TSH有关。
