Verna L, Whysner J, Williams G M
Toxicology and Risk Assessment Program, American Health Foundation, Valhalla, NY 10595-1599, USA.
Pharmacol Ther. 1996;71(1-2):57-81. doi: 10.1016/0163-7258(96)00062-9.
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in every animal species tested. Bioactivation is effected by several P450 isozymes including CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-ethyldeoxythymidine formation in DNA, which was generally proportional to NDEA dose. At low doses in the 0.033-1.1 ppm range, the dose-response for esophageal tumor formation was sublinear, possibly due to DNA repair. Although no epidemiological studies have specifically evaluated NDEA, sufficient exposure levels would be expected to cause cancer in humans.
N-亚硝基二乙胺（NDEA）经生物活化后具有DNA反应性，并在每一种受试动物物种中诱发肿瘤。生物活化由包括CYP2E1在内的几种细胞色素P450同工酶介导，CYP2E1可被乙醇诱导。大鼠肝脏中的肿瘤形成与DNA中O4-乙基脱氧胸苷的形成成正比，而这通常与NDEA剂量成正比。在0.033 - 1.1 ppm的低剂量范围内，食管肿瘤形成的剂量反应呈亚线性，可能是由于DNA修复所致。尽管尚无流行病学研究专门评估NDEA，但预计足够的暴露水平会导致人类患癌。
