O'Malley C D, Shaw G M, Wasserman C R, Lammer E J
March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville 94608, USA.
Teratology. 1996 Jun;53(6):374-7. doi: 10.1002/(SICI)1096-9926(199606)53:6<374::AID-TERA8>3.0.CO;2-#.
In this population-based case-control study, we explored the association of selected parental and infant characteristics from the birth certificates of children with conotruncal heart defects. We compared 252 cases to a random sample of 5,000 nonmalformed infants from a cohort of 341,839 California live births for 1987-1988. The prevalence of conotruncal defects was 0.732 per 1,000 total births. A decreased risk (OR = 0.55, 95% CI0.33-0.89) for delivering infants with conotruncal defects was found among mothers born in Mexico compared to mothers born in California. An increased risk was observed for Native American mothers compared to non-Hispanic whites (OR = 2.6, 95% CI 1.1-6.0). We also compared risks associated with the individual diagnoses that comprise the group of conotruncal defects. Only minor differences in risk estimates between the anatomic diagnoses were observed, lending support to the methodologic approach of using conotruncal defects as a single category of heart defects in etiologic investigations.
在这项基于人群的病例对照研究中，我们从患有圆锥干心脏缺陷儿童的出生证明中探究了选定的父母及婴儿特征之间的关联。我们将252例病例与从1987 - 1988年加利福尼亚州341,839例活产队列中随机抽取的5000例无畸形婴儿进行了比较。圆锥干缺陷的患病率为每1000例总出生数中有0.732例。与出生在加利福尼亚州的母亲相比，出生在墨西哥的母亲分娩患有圆锥干缺陷婴儿的风险降低（比值比 = 0.55，95%可信区间0.33 - 0.89）。与非西班牙裔白人母亲相比，美国原住民母亲的风险增加（比值比 = 2.6，95%可信区间1.1 - 6.0）。我们还比较了与构成圆锥干缺陷组的各个诊断相关的风险。在解剖学诊断之间仅观察到风险估计值的微小差异，这支持了在病因学研究中将圆锥干缺陷作为单一类别心脏缺陷的方法学途径。
