Piafsky K M, Sitar D S, Ogilvie R I
Clin Pharmacol Ther. 1977 Sep;22(3):336-9. doi: 10.1002/cpt1977223336.
The disposition of intravenous doses of theophylline was determined in normal male subjects before and after treatment with phenobarbital 2 wk. Although there was some variation in disposition of the 2 drugs, there were no significant effects of phenobarbital on theophylline kinetics. We conclude that theophylline dosage need not be altered during concomitant administration of phenobarbital.
在正常男性受试者中，测定了苯巴比妥治疗2周前后静脉注射茶碱的处置情况。尽管两种药物的处置存在一些差异，但苯巴比妥对茶碱动力学没有显著影响。我们得出结论，在同时给予苯巴比妥期间，无需改变茶碱的剂量。
