Aranda J V, Collinge J M, Zinman R, Watters G
Arch Dis Child. 1979 Dec;54(12):946-9. doi: 10.1136/adc.54.12.946.
The developmental changes in caffeine elimination were studied in 7 infants aged between 2 1/2 weeks and 6 months. Adult plasma clearance rate of caffeine was achieved at 3 to 4 1/2 months of age. Plasma half-life and elimination rate reached adult levels after 3 to 4 1/2 months and seemed to exceed adult capacity thereafter. No significant changes in apparent volume of distribution were noted. Our data provide some indication of the age in infancy when the low rates of caffeine elimination in the neonate increase to the adult rate.
对7名年龄在2.5周至6个月之间的婴儿进行了咖啡因消除的发育变化研究。咖啡因的成人血浆清除率在3至4.5个月大时达到。血浆半衰期和消除率在3至4.5个月后达到成人水平，此后似乎超过了成人水平。分布表观容积没有显著变化。我们的数据提供了一些关于婴儿期年龄的指示，即新生儿期低咖啡因消除率增加到成人率的年龄。
