• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cloning and sequencing of the group 6 allergen of Dermatophagoides pteronyssinus.

作者信息

Bennett B J, Thomas W R

机构信息

TVW Telethon Institute for Child Health Research, Perth, Australia.

出版信息

Clin Exp Allergy. 1996 Oct;26(10):1150-4.

PMID:8911700
Abstract

BACKGROUND

The allergen Der p 6 from Dermatophagoides pteronyssinus has been described by substrate affinity as mite chymotrypsin.

OBJECTIVE

The aim of this paper was to describe a cDNA clone encoding the allergen.

METHODS

cDNA was cloned from a lambda library using oligonucleotides published for Der p 6.

RESULTS

The clone P6.1.1 had the N-terminal amino acid residues as reported for Der p 6, and at position 189 the Ser was conserved in chymotrypsin for substrate specificity as well as the catalytic triad of His57, Asp102 and Ser195 for serine proteases. The estimated M(r) was 24.9K and it was 37% identical to the trypsin allergen Der p 3.

CONCLUSION

cDNA encoding Der p 6 has been described.

摘要

相似文献

1
Cloning and sequencing of the group 6 allergen of Dermatophagoides pteronyssinus.
Clin Exp Allergy. 1996 Oct;26(10):1150-4.
2
Sequence polymorphisms of the Der p 3 house dust mite allergen.屋尘螨变应原Der p 3的序列多态性
Clin Exp Allergy. 1996 May;26(5):571-9.
3
Analysis of sequence polymorphism of a major mite allergen, Der p 2.一种主要螨类过敏原Der p 2的序列多态性分析
Clin Exp Allergy. 1996 Jul;26(7):829-37.
4
Characterization of Der p 21, a new important allergen derived from the gut of house dust mites.屋尘螨肠道来源的一种新的重要变应原Der p 21的特性分析
Allergy. 2008 Jun;63(6):758-67. doi: 10.1111/j.1398-9995.2008.01647.x.
5
Cloning and sequencing of the Dermatophagoides pteronyssinus group III allergen, Der p III.屋尘螨第三组变应原Der p III的克隆与测序
Clin Exp Allergy. 1994 Mar;24(3):220-8. doi: 10.1111/j.1365-2222.1994.tb00223.x.
6
Molecular cloning and characterization of full-length cDNAs encoding a novel high-molecular-weight Dermatophagoides pteronyssinus mite allergen, Der p 11.编码新型高分子量屋尘螨变应原Der p 11的全长cDNA的分子克隆与特性分析
Allergy. 2005 Jul;60(7):927-37. doi: 10.1111/j.1398-9995.2005.00637.x.
7
Acid-induced polymerization of the group 5 mite allergen from Dermatophagoides pteronyssinus.
Biochem Biophys Res Commun. 2001 Jul 13;285(2):308-12. doi: 10.1006/bbrc.2001.5184.
8
Cloning, sequence analysis and expression in E. coli of the group 3 allergen of Dermatophagoides farinae.粉尘螨 3 组变应原的克隆、序列分析及在大肠杆菌中的表达。
Chin Med J (Engl). 2009 Nov 5;122(21):2657-61.
9
[cDNA cloning and sequence analysis of major allergen of Dermatophagoides farinae (Der f 2) in south China].[中国南方粉尘螨主要变应原（Der f 2）的cDNA克隆及序列分析]
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2003;21(3):160-3.
10
[Cloning, sequencing and subcloning of cDNA coding for group I allergen of Dermatophagoides farinae].[粉尘螨Ⅰ类变应原编码cDNA的克隆、测序及亚克隆]
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2004 Jun;22(3):173-5.

引用本文的文献

1
Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease.空气传播的室内过敏原丝氨酸蛋白酶及其在过敏性气道疾病中对致敏和先天免疫激活的作用。
Eur Respir Rev. 2024 Apr 24;33(172). doi: 10.1183/16000617.0126-2023. Print 2024 Apr 30.
2
Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma.深入了解屋尘螨介导的变应性哮喘中的黏膜先天免疫反应。
Front Immunol. 2020 Dec 7;11:534501. doi: 10.3389/fimmu.2020.534501. eCollection 2020.
3
IgE, IgG1, and IgG4 Reactivity to Glycosylated Extract in Allergic Patients.
变应性患者中 IgE、IgG1 和 IgG4 对糖基化提取物的反应性。
Biomed Res Int. 2019 Jul 29;2019:9840890. doi: 10.1155/2019/9840890. eCollection 2019.
4
Profiling the Extended Cleavage Specificity of the House Dust Mite Protease Allergens Der p 1, Der p 3 and Der p 6 for the Prediction of New Cell Surface Protein Substrates.分析屋尘螨蛋白酶过敏原Der p 1、Der p 3和Der p 6的扩展切割特异性以预测新的细胞表面蛋白底物
Int J Mol Sci. 2017 Jun 27;18(7):1373. doi: 10.3390/ijms18071373.
5
Allergens with Protease Activity from House Dust Mites.来自屋尘螨的具有蛋白酶活性的变应原
Int J Mol Sci. 2017 Jun 27;18(7):1368. doi: 10.3390/ijms18071368.
6
Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases.Der f 34，一种新型主要屋尘螨变应原，属于高度保守的亚胺脱氨酶Rid/YjgF/YER057c/UK114家族。
J Biol Chem. 2016 Oct 7;291(41):21607-21615. doi: 10.1074/jbc.M116.728006. Epub 2016 Aug 18.
7
Analysis of T-cell epitopes of Der f3 in Dermatophagoides farina.粉尘螨中Der f3的T细胞表位分析
Int J Clin Exp Pathol. 2015 Jan 1;8(1):137-45. eCollection 2015.
8
Allergenic characterization of a novel allergen, homologous to chymotrypsin, from german cockroach.一种新型过敏原的变应原性特征，与德国蟑螂的胰凝乳蛋白酶同源。
Allergy Asthma Immunol Res. 2015 May;7(3):283-9. doi: 10.4168/aair.2015.7.3.283. Epub 2014 Dec 18.
9
Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet.屋尘螨蛋白酶变应原四重奏罕见成熟级联的编排。
Front Immunol. 2014 Mar 31;5:138. doi: 10.3389/fimmu.2014.00138. eCollection 2014.
10
Role of Allergen Source-Derived Proteases in Sensitization via Airway Epithelial Cells.变应原来源的蛋白酶在通过气道上皮细胞致敏过程中的作用。
J Allergy (Cairo). 2012;2012:903659. doi: 10.1155/2012/903659. Epub 2012 Feb 27.