Dills D G, Schneider J
Department of Medicine, University of Wisconsin, Madison, USA.
Horm Metab Res. 1996 Sep;28(9):426-9. doi: 10.1055/s-2007-979831.
We report on the results of a one-year, multicenter, randomized, double-blind, parallel-group titration study of the new sulfonylurea agent, glimepiride, versus use of non-micronized glyburide to treat 577 patients with non-insulin dependent diabetes mellitus (NIDDM). Similar decreases in both fasting plasma glucose and HbA1C were found using glimepiride and glyburide. There was a lower incidence of hypoglycemia with glimepiride than glyburide.
我们报告了一项为期一年的多中心随机双盲平行组滴定研究结果，该研究对比了新型磺脲类药物格列美脲与非微粉化格列本脲治疗577例非胰岛素依赖型糖尿病（NIDDM）患者的疗效。使用格列美脲和格列本脲时，空腹血糖和糖化血红蛋白（HbA1C）均有相似程度的下降。与格列本脲相比，格列美脲导致低血糖的发生率更低。
