De Groot A C, van Ginkel C J, Weijland J W
Department of Dermatology, Carolus-Liduina Hospital, 's-Hertogenbosch.
J Am Acad Dermatol. 1996 Nov;35(5 Pt 1):743-7. doi: 10.1016/s0190-9622(96)90730-6.
Euxyl K 400 is a preservative system for cosmetics and toiletries that contains phenoxyethanol and methyldibromoglutaronitrile in a 4:1 ratio. In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4 years and is currently 2% to 4% in patients suspected of having contact dermatitis. The allergenic ingredient is nearly always methyldibromoglutaronitrile. Causative products include both stay-on and rinse-off cosmetics and moistened toilet tissue. Because the causative products usually give false-negative reactions, the allergen, methyldibromoglutaronitrile, should be tested in all patients suspected of having cosmetic dermatitis and in those with perianal dermatitis. We suggest a test concentration of 0.3% to 0.5% in petrolatum.
优溪K400是一种用于化妆品和洗漱用品的防腐剂体系，其含有按4:1比例混合的苯氧乙醇和甲基二溴戊二腈。在荷兰、意大利和德国，过去4年中对优溪K400过敏的患病率有所上升，目前在疑似接触性皮炎的患者中为2%至4%。几乎总是甲基二溴戊二腈这种成分具有致敏性。致病产品包括驻留型和冲洗型化妆品以及湿厕纸。由于致病产品通常会产生假阴性反应，对于所有疑似化妆品皮炎的患者以及肛周皮炎患者，都应检测过敏原甲基二溴戊二腈。我们建议在凡士林制剂中的测试浓度为0.3%至0.5%。
