Sakai K, Hisanaga N, Okuno M, Kohyama N, Shinohara Y, Shibata E, Kamijima M, Yamanaka K, Takeuchi Y
Nagoya City Public Health Research Institute.
Nihon Koshu Eisei Zasshi. 1996 Jul;43(7):551-62.
Concentrations and fiber size distribution of asbestos in the lung tissue of 16 ( 8 males and 8 females) rural residents living close to the serpentinite area (neighboring group) were analyzed by low temperature ashing-analytical transmission electron microscopy, and were compared with those of 5 (5 males) rural and 53 (34 males and 19 females) urban residents living away from the serpentinite area (reference group). The results are as follows; 1. Pulmonary asbestos fibers were found in all rural residents. The types of asbestos fibers were chrysotile, amosite, crocidolite, actinolite, and tremolite. These findings were very similar to results for urban residents. 2. In males, the geometric mean concentration of actinolite-tremolite in the neighboring group (1.78 x 10(6) fibers/g dry lung) was significantly higher than those in the reference groups (rural: 0.32 x 10(6), urban: 0.31 x 10(6), p < 0.01). In females also, the geometric mean concentration of actinolite-tremolite in the neighboring group (0.59 x 10(6)) was significantly higher than that in the reference group (urban: 0.16 x 10(6), p < 0.05). There were no significant differences in the actinolite-tremolite concentrations between males and females in the neighboring group. 3. The serpentinite in this area have contained not only chrysotile but also both actinolite and tremolite. There was no significant relationship between actinolite-tremolite concentration and occupational history in the neighboring group. It is possible that actinolite and tremolite are liberated from the serpentinite to the atmosphere and inhaled by the residents near the serpentinite area which increases pulmonary actinolite-tremolite concentration. 4. The difference in the geometric mean concentration of chrysotile between the neighboring and the reference group was not statistically significant for both sexes, possibly due to the poor durability of chrysotile in the lung tissue. 5. There were no significant differences in the geometric mean of fiber length and diameter of actinolite-tremolite between the neighboring and the reference group.
通过低温灰化-分析透射电子显微镜对居住在蛇纹岩地区附近的16名（8名男性和8名女性）农村居民（邻组）肺组织中的石棉浓度和纤维大小分布进行了分析，并与5名（5名男性）居住在远离蛇纹岩地区的农村居民和53名（34名男性和19名女性）城市居民（参照组）的进行了比较。结果如下：1. 在所有农村居民中均发现了肺石棉纤维。石棉纤维类型有温石棉、铁石棉、青石棉、阳起石和透闪石。这些发现与城市居民的结果非常相似。2. 在男性中，邻组阳起石-透闪石的几何平均浓度（1.78×10⁶根纤维/克干肺）显著高于参照组（农村：0.32×10⁶，城市：0.31×10⁶，p<0.01）。在女性中，邻组阳起石-透闪石的几何平均浓度（0.59×10⁶）也显著高于参照组（城市：0.16×10⁶，p<0.05）。邻组中男性和女性的阳起石-透闪石浓度无显著差异。3. 该地区的蛇纹岩不仅含有温石棉，还含有阳起石和透闪石。邻组中阳起石-透闪石浓度与职业史之间无显著关系。阳起石和透闪石有可能从蛇纹岩中释放到大气中，并被蛇纹岩地区附近的居民吸入，从而增加了肺中阳起石-透闪石的浓度。4. 邻组和参照组之间温石棉几何平均浓度的差异在两性中均无统计学意义，这可能是由于温石棉在肺组织中的耐久性较差。5. 邻组和参照组之间阳起石-透闪石纤维长度和直径的几何平均值无显著差异。
