环丙沙星和哌拉西林在梗阻性胆道中的胆汁排泄。
Biliary excretion of ciprofloxacin and piperacillin in the obstructed biliary tract.
作者信息
van den Hazel S J, de Vries X H, Speelman P, Dankert J, Tytgat G N, Huibregtse K, van Leeuwen D J
机构信息
Department of Gastroenterology and Hepatology, University of Amsterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1996 Nov;40(11):2658-60. doi: 10.1128/AAC.40.11.2658.
Abstract
Biliary excretion of ciprofloxacin and piperacillin was determined in cholestatic patients who had undergone endoscopic cholangiography. The median concentration of ciprofloxacin (n = 9) was 2.36 micrograms/ml (range, 0.29 to 19.8 micrograms/ml) in bile compared with 1.66 micrograms/ml (range, 0.73 to 2.69 micrograms/ml) in serum. The median concentration of piperacillin (n = 7) was < 5 micrograms/ml (range, < 5 to 26) in bile compared with 14.3 micrograms/ml (range, 5.3 to 80) in serum. Ciprofloxacin, but not piperacillin, can be actively excreted into bile in the presence of a biliary tract obstruction.
摘要
在接受内镜胆管造影的胆汁淤积患者中测定了环丙沙星和哌拉西林的胆汁排泄情况。环丙沙星（n = 9）在胆汁中的中位浓度为2.36微克/毫升（范围为0.29至19.8微克/毫升），而在血清中的中位浓度为1.66微克/毫升（范围为0.73至2.69微克/毫升）。哌拉西林（n = 7）在胆汁中的中位浓度<5微克/毫升（范围为<5至26），而在血清中的中位浓度为14.3微克/毫升（范围为5.3至80）。在存在胆道梗阻的情况下，环丙沙星可被主动排泄到胆汁中，而哌拉西林则不能。
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