Syntheses and some applications of chemically defined multivalent glycoconjugates.

Classical multivalent neoglycoproteins have been widely used to study a great number of carbohydrate-protein interactions. The synthesis of other neoglycoconjugates with various shapes, valencies, and conformations has reached considerable levels of sophistication and holds promise as a new tool for glycobiology and biomedical applications. Within the last few years, advances have been made towards both the syntheses and understanding of the antigenic properties of water-soluble glycopolymers. Some of these glycopolymers are finding applications as inhibitors of microbial adhesins and as carriers for drug delivery to specific cells. Novel dendritic carbohydrate structures are emerging as potent ligands for carbohydrate-binding proteins.