Roy R
Department of Chemistry, University of Ottawa, Ontario, Canada.
Curr Opin Struct Biol. 1996 Oct;6(5):692-702. doi: 10.1016/s0959-440x(96)80037-6.
Classical multivalent neoglycoproteins have been widely used to study a great number of carbohydrate-protein interactions. The synthesis of other neoglycoconjugates with various shapes, valencies, and conformations has reached considerable levels of sophistication and holds promise as a new tool for glycobiology and biomedical applications. Within the last few years, advances have been made towards both the syntheses and understanding of the antigenic properties of water-soluble glycopolymers. Some of these glycopolymers are finding applications as inhibitors of microbial adhesins and as carriers for drug delivery to specific cells. Novel dendritic carbohydrate structures are emerging as potent ligands for carbohydrate-binding proteins.
经典的多价新糖蛋白已被广泛用于研究大量的碳水化合物-蛋白质相互作用。其他具有各种形状、价态和构象的新糖缀合物的合成已达到相当复杂的程度，并有望成为糖生物学和生物医学应用的新工具。在过去几年中，在水溶性糖聚合物的合成及其抗原特性的理解方面都取得了进展。其中一些糖聚合物正被用作微生物粘附素的抑制剂以及向特定细胞输送药物的载体。新型树枝状碳水化合物结构正作为碳水化合物结合蛋白的有效配体而出现。
