Biktashev V N, Holden A V
Institute for Mathematical Problems in Biology, Pushchino, Moscow Region, Russia.
Proc Biol Sci. 1996 Oct 22;263(1375):1373-82. doi: 10.1098/rspb.1996.0201.
We characterize the meander of re-entrant excitation in a model of a sheet of mammalian ventricular tissue, and its control by resonant drift under feedback driven stimulation. The Oxsoft equations for excitability in a guinea pig single ventricular cell were incorporated in a two dimensional reaction-diffusion system to model homogeneous, isotropic tissue with a plane wave conduction velocity of 0.35 m s-1. Re-entrant spiral wave solutions have a spatially extended transient motion (linear core) that settles down into rotation with an irregular period of 100-110 ms around an irregular, multi-lobed spiky core. In anisotropic tissue this would appear as a linear conduction block. The typical velocity of drift of the spiral wave induced by low amplitude resonant forcing is 0.4 cm s-1.
我们对一片哺乳动物心室组织模型中的折返激动的曲折进行了表征，以及在反馈驱动刺激下通过共振漂移对其进行的控制。将豚鼠单个心室细胞兴奋性的Oxsoft方程纳入二维反应扩散系统，以模拟具有0.35米/秒平面波传导速度的均匀、各向同性组织。折返螺旋波解具有空间扩展的瞬态运动（线性核心），该运动在围绕不规则的多叶尖峰核心以100 - 110毫秒的不规则周期稳定旋转。在各向异性组织中，这将表现为线性传导阻滞。由低振幅共振强迫引起的螺旋波典型漂移速度为0.4厘米/秒。
