Biktashev V N, Holden A V
Institute of Mathematical Problems of Biology, Pushchino, Moscow region, Russia.
Proc Biol Sci. 1995 May 22;260(1358):211-7. doi: 10.1098/rspb.1995.0082.
We evaluate the feasibility of using resonant drift under feedback driven stimulation to control re-entrant excitation in atrial muscle. We simulate a two-dimensional sheet of atrial tissue, where the local kinetics are described by the Earm-Hilgemann-Noble equations for a rabbit atrial cell, and the effects of small amplitude spatially uniform forcing of the whole sheet are computed. Repetitive forcing can induce a drift of a spiral wave in the two-dimensional model, with a drift velocity of up to 10 cm s-1. For a 4 cm x 4 cm atrial surface this resonant drift can move the re-entrant spiral to the inexcitable boundaries, eliminating re-entry in less than 10 s when the amplitude of the repetitive stimulation is 10% that of the single shock defibrillation threshold.
我们评估了在反馈驱动刺激下利用共振漂移来控制心房肌中折返性兴奋的可行性。我们模拟了二维心房组织片，其中局部动力学由兔心房细胞的Earm-Hilgemann-Noble方程描述，并计算了对整个组织片施加小幅度空间均匀强迫的影响。重复强迫可在二维模型中诱导螺旋波的漂移，漂移速度可达10厘米/秒。对于4厘米×4厘米的心房表面，当重复刺激的幅度为单次电击除颤阈值的10%时，这种共振漂移可将折返螺旋波移至不可兴奋边界，在不到10秒的时间内消除折返。
