Li Y, Deeb B, Pendergrass W, Wolf N
Department of Pathology, University of Washington, Seattle, USA.
J Gerontol A Biol Sci Med Sci. 1996 Nov;51(6):B403-8. doi: 10.1093/gerona/51a.6.b403.
In a study comparing animal life spans and in vitro clonal proliferative capacity of skin fibroblasts in groupings of small, middle, large, and very large breeds of dogs of specific ages, the following results were obtained: (1) their life spans were inversely correlated to the frame sizes of the breeds; (2) the percent of large clones present in clone size distributions from the small dogs was inversely proportional to the age of the subjects (this was not true for the large breeds; however, animals older than 8 years were not available in those breeds); and (3) the group composed of the two largest breeds (Great Dane and Irish Wolfhound) had the shortest life spans and also had significantly smaller percentages of large skin fibroblast clones formed in vitro than either of the two groupings of smaller dogs at any age studied. It appears that within the domestic dogs the large body size is accompanied by shorter life span and, in the two largest breeds, decreased cellular growth potential.
在一项针对特定年龄的小型、中型、大型和超大型犬种分组，比较动物寿命和皮肤成纤维细胞体外克隆增殖能力的研究中，获得了以下结果：（1）它们的寿命与犬种的体格大小呈负相关；（2）小型犬克隆大小分布中大型克隆的百分比与受试动物的年龄呈反比（大型犬种并非如此；然而，这些犬种中没有8岁以上的动物）；（3）由两个最大犬种（大丹犬和爱尔兰猎狼犬）组成的组寿命最短，并且在任何研究年龄下，体外形成的大型皮肤成纤维细胞克隆的百分比也明显低于两组较小犬种中的任何一组。看来在家犬中，大体型伴随着较短的寿命，并且在两个最大的犬种中，细胞生长潜力降低。
