Bent J P, Kuhn F A
Division of Otolaryngology, The Medical College of Georgia, Augusta 30912-4060, USA.
Laryngoscope. 1996 Nov;106(11):1331-4. doi: 10.1097/00005537-199611000-00005.
A review of more than 50 allergic fungal sinusitis (AFS) patients indicates that most patients experience postoperative recurrences once weaned from oral steroids, leaving a glaring need for improved treatment. Topical antifungal therapy has not been described for AFS, but it could potentially lower fungal antigen loads via postoperative irrigations. No information exists to direct the choice of antifungal agent. The purpose of this study was to identify the appropriate drug to use for postoperative irrigations in AFS patients. Twenty-two fungal cultures grown from 15 AFS patients were studied for in vitro susceptibility to five common antifungal drugs: ketoconazole, amphotericin B, itraconazole, nystatin, and fluconazole. Results demonstrated that ketoconazole and amphotericin B were the most effective. Clinical trials are indicated to evaluate the efficacy of these drugs as a supplement to current AFS treatment.
一项对50多名变应性真菌性鼻窦炎（AFS）患者的回顾表明，大多数患者在停用口服类固醇后会出现术后复发，这凸显了改进治疗方法的迫切需求。目前尚未有关于AFS局部抗真菌治疗的描述，但通过术后冲洗可能会降低真菌抗原负荷。目前尚无指导抗真菌药物选择的信息。本研究的目的是确定AFS患者术后冲洗适合使用的药物。对从15例AFS患者中培养出的22株真菌进行了体外药敏试验，检测其对五种常用抗真菌药物的敏感性：酮康唑、两性霉素B、伊曲康唑、制霉菌素和氟康唑。结果表明，酮康唑和两性霉素B最为有效。需要开展临床试验来评估这些药物作为当前AFS治疗补充手段的疗效。
