新生儿与成年男性血浆蛋白结合药物的差异。I.
Differences in the binding of drugs to plasma proteins from newborn and adult man. I.
作者信息
Kurz H, Mauser-Ganshorn A, Stickel H H
出版信息
Eur J Clin Pharmacol. 1977 Jul 19;11(6):463-7. doi: 10.1007/BF00562940.
PMID:891592
Abstract
The binding of various drugs to plasma proteins from adult and cord plasma was determined by equilibrium dialysis. For almost all the drugs binding to cord plasma was lower than to plasma from adults. No evidence was found that the difference in binding was due to the different protein concentration in cord and adult plasma or to an influence of substances in ultrafiltrates of the plasmas.
摘要
通过平衡透析法测定了多种药物与成人血浆和脐血血浆中血浆蛋白的结合情况。几乎所有药物与脐血血浆的结合都低于与成人血浆的结合。未发现结合差异是由于脐血血浆和成人血浆中蛋白质浓度不同，或血浆超滤物中物质的影响所致。
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