Ribotsky B M, Berkowitz K D, Montague J R
American Board of Podiatric Surgery, Boca Raton, FL 33486, USA.
J Am Podiatr Med Assoc. 1996 Oct;86(10):487-91. doi: 10.7547/87507315-86-10-487.
The advantages to using a 50/50 mixture of lidocaine and bupivacaine with respect to onset and duration of local anesthesia instead of using the solutions independently were evaluated. In a double-blind randomized experiment, 12 subjects, each volunteering both feet, were studied. One foot was injected with 1 ml of one of the following three solutions: 1% plain lidocaine, 0.25% plain bupivacaine (Marcaine), or a 50/50 mixture of 1% lidocaine and 0.25% bupivacaine; and in the other foot, a 1-ml injection of normal saline as a blinded control. A 5.07 (10 g) Semmes-Weinstein monofilament wire was used for testing for sensory blockade, and the onset and duration of anesthesia was recorded for each subject. It was determined that there was no significant difference in the mean onset times for the three solutions, and no significant difference between the durations of anesthesia of plain lidocaine and the 50/50 mixture. Additionally, it was determined that bupivacaine had a prolonged duration of anesthesia compared with the other two solutions. The results of this preliminary study suggest that there is no clinical advantage, with respect to onset and duration of local blockade, to using a 50/50 mixture of plain lidocaine and plain bupivacaine in place of their independent use.
评估了使用利多卡因和布比卡因50/50混合液相对于单独使用这两种溶液进行局部麻醉时在起效时间和持续时间方面的优势。在一项双盲随机实验中，对12名受试者进行了研究，每名受试者的双脚均自愿参与。一只脚注射1毫升以下三种溶液之一：1%的单纯利多卡因、0.25%的单纯布比卡因（耐乐品）或1%利多卡因与0.25%布比卡因的50/50混合液；另一只脚注射1毫升生理盐水作为盲法对照。使用5.07（10克）的Semmes-Weinstein单丝进行感觉阻滞测试，并记录每名受试者的麻醉起效时间和持续时间。结果发现，三种溶液的平均起效时间没有显著差异，单纯利多卡因和50/50混合液的麻醉持续时间之间也没有显著差异。此外，还发现布比卡因的麻醉持续时间比其他两种溶液更长。这项初步研究的结果表明，就局部阻滞的起效时间和持续时间而言，使用单纯利多卡因和单纯布比卡因的50/50混合液代替单独使用它们并没有临床优势。
