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Synthesis and properties of Praziquantel, a novel broad spectrum anthelmintic with excellent activity against Schistosomes and Cestodes.

作者信息

Seubert J, Pohlke R, Loebich F

出版信息

Experientia. 1977 Aug 15;33(8):1036-7. doi: 10.1007/BF01945954.

DOI:10.1007/BF01945954
PMID:891804
Abstract

Synthesis and properties of 2-cyclohexylcarbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino [2,1-a] isoquinolin-4-one, a novel anthelmintic with excellent activity against all species of Schistosomes pathogenic to man and a wide range of cestodes, will be reported.

摘要

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Synthesis and properties of Praziquantel, a novel broad spectrum anthelmintic with excellent activity against Schistosomes and Cestodes.
Experientia. 1977 Aug 15;33(8):1036-7. doi: 10.1007/BF01945954.
2
Toxicological profile of praziquantel, a new drug against cestode and schistosome infections, as compared to some other schistosomicides.与其他一些抗血吸虫药物相比，新型抗绦虫和血吸虫感染药物吡喹酮的毒理学概况。
Arzneimittelforschung. 1981;31(3a):555-65.
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Arzneimittelforschung. 1981;31(3a):538-41.
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Synthetic and bioorganic investigations of 2-cyclohexylthiocarbonyl( 1,2,3,6,7,11B)hexahydro-4H-pyrazino [2-1a] isoquinoline-4-thione, a new dithione mimic of the universal anthelminthic Praziquantel.2-环己基硫代羰基（1,2,3,6,7,11B）六氢-4H-吡嗪并[2-1a]异喹啉-4-硫酮的合成及生物有机研究，一种新型的广谱驱虫药吡喹酮的二硫酮类似物。
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[Synthesis, anthelmintic activity and acute toxicity of an isoquinoline pyrazine derivative (2-acyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4-ones].一种异喹啉吡嗪衍生物（2-酰基-1,2,3,6,7,11b-六氢-4H-吡嗪并[2,1-a]异喹啉-4-酮）的合成、驱虫活性及急性毒性
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J Med Chem. 1989 Sep;32(9):2058-62. doi: 10.1021/jm00129a007.

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本文引用的文献

1
The schistosomiasis problem.血吸虫病问题。
World Med J. 1967 Jan-Feb;14(1):18-9.
2
Anthelmintics, new and old.
Clin Pharmacol Ther. 1969 Jan-Feb;10(1):5-21. doi: 10.1002/cpt19691015.
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[The efficacy of praziquantel against tapeworms in experimentally infected dogs and cats].吡喹酮对实验感染犬猫绦虫的疗效
Berl Munch Tierarztl Wochenschr. 1976 Jul 1;89(13):255-7.
Genomic basis of schistosome resistance in a molluscan vector of human schistosomiasis.人类血吸虫病软体动物宿主中血吸虫抗性的基因组基础。
iScience. 2024 Dec 2;28(1):111520. doi: 10.1016/j.isci.2024.111520. eCollection 2025 Jan 17.
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A haplotype-like, chromosome-level assembled and annotated genome of Biomphalaria glabrata, an important intermediate host of schistosomiasis and the best studied model of schistosomiasis vector snails.布氏日本血吸虫中间宿主福寿螺的一种类似单倍型的、染色体水平组装和注释基因组，是血吸虫病的重要中间宿主，也是研究最为深入的血吸虫病传播螺类模型。
PLoS Negl Trop Dis. 2024 Feb 29;18(2):e0011983. doi: 10.1371/journal.pntd.0011983. eCollection 2024 Feb.
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Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping.蜗牛与血吸虫的兼容性：来自新遗传资源、比较基因组学和遗传图谱的见解。
Commun Biol. 2022 Sep 9;5(1):940. doi: 10.1038/s42003-022-03844-5.
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Urogenital Schistosomiasis-History, Pathogenesis, and Bladder Cancer.泌尿生殖系统血吸虫病——历史、发病机制与膀胱癌
J Clin Med. 2021 Jan 8;10(2):205. doi: 10.3390/jcm10020205.
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In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni.载姜黄素纳米粒抗曼氏血吸虫作用的体内评价与吡喹酮治疗曼氏血吸虫病的比较。
Sci Rep. 2020 Sep 25;10(1):15742. doi: 10.1038/s41598-020-72901-y.
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Am J Trop Med Hyg. 2020 Jul;103(1_Suppl):1-4. doi: 10.4269/ajtmh.19-0838.
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PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004131. doi: 10.1371/journal.pntd.0004131. eCollection 2015.