Chen R, Seaton A
Department of Environmental & Occupational Medicine, Medical School, University of Aberdeen, UK.
Occup Med (Lond). 1996 Oct;46(5):337-44. doi: 10.1093/occmed/46.5.337.
It has been suggested that organic solvent exposure may contribute to an increased risk of blood disorders, neurological, liver and renal disease, and cancer. A meta-analysis has been performed of 55 published mortality studies which involved solvent exposure and provided standardised mortality ratios (SMR) or relative risk (RR). The combined results showed the overall SMR to be 86.7 (95% confidence interval [Cl] = 83.7-89.9), while that for all sites of cancer was 92.3 (Cl = 87.5-97.4). Risk of death from leukaemia was increased (SMR = 112.2, Cl = 101.6-146.9) as was that from cancer of liver and biliary passages (SMR = 119.7, Cl = 104.4-137.2), even though the risk of death from cirrhosis was reduced (SMR = 81.5, Cl = 68.1-97.4). No excess risk of death from other diseases has been found. The favourable mortality might be from a "healthy worker effect', but the increase in death from liver cancer in the absence of excess deaths from cirrhosis is biologically plausible and justifies further investigation. The increase in mortality from leukaemia is likely to have been associated with exposure to benzene.
有人提出，接触有机溶剂可能会增加患血液疾病、神经疾病、肝脏和肾脏疾病以及癌症的风险。对55项已发表的死亡率研究进行了荟萃分析，这些研究涉及溶剂接触并提供了标准化死亡率比值（SMR）或相对风险（RR）。综合结果显示总体SMR为86.7（95%置信区间[Cl]=83.7 - 89.9），而所有癌症部位的SMR为92.3（Cl = 87.5 - 97.4）。白血病死亡风险增加（SMR = 112.2，Cl = 101.6 - 146.9），肝脏和胆道癌症死亡风险也增加（SMR = 119.7，Cl = 104.4 - 137.2），尽管肝硬化死亡风险降低（SMR = 81.5，Cl = 68.1 - 97.4）。未发现其他疾病存在额外的死亡风险。有利的死亡率可能来自“健康工人效应”，但在没有肝硬化超额死亡的情况下肝癌死亡增加在生物学上是合理的，值得进一步研究。白血病死亡率的增加可能与接触苯有关。
