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血管系统及血管相关疾病中硫醇的生物化学

Biological chemistry of thiols in the vasculature and in vascular-related disease.

作者信息

Stamler J S, Slivka A

机构信息

Department of Medicine, Duke Medical Center, Durham, NC, USA.

出版信息

Nutr Rev. 1996 Jan;54(1 Pt 1):1-30. doi: 10.1111/j.1753-4887.1996.tb03770.x.

DOI:10.1111/j.1753-4887.1996.tb03770.x
PMID:8919695
Abstract

For all their similarities in structure and common chemistry, the functions of the amino thiols in vascular biology are remarkably different. This review details the basic chemistry of sulfhydryls that dictates their functions in health and disease. In addition, the biochemistry and metabolism of each thiol are outlined, in an effort to highlight its specific contributions to the normal biology and physiology of blood vessels and to the pathogenesis of vascular-related disease.

摘要

尽管氨基硫醇在结构和常见化学性质上有诸多相似之处,但它们在血管生物学中的功能却显著不同。本综述详细阐述了巯基的基础化学,这些化学性质决定了它们在健康和疾病中的功能。此外,还概述了每种硫醇的生物化学和代谢过程,旨在突出其对血管正常生物学和生理学以及血管相关疾病发病机制的具体贡献。

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