Wolf G
Department of Nutritional Sciences University of California, Berkeley 94720-3104, USA.
Nutr Rev. 1996 Jan;54(1 Pt 1):34-5. doi: 10.1111/j.1753-4887.1996.tb03772.x.
Earlier work with human subjects showed that a low-fat, low-cholesterol diet lowered plasma high-density-lipoprotein-cholesterol (HDL-C) and the production rate of apolipoprotein A-I (apo A-I). More recent research with transgenic mice demonstrated that a high-fat, high-cholesterol diet raised plasma HDL-C and the production rate of apo A-I by a mechanism involving the regulation of translation of the apo A-I mRNA. The authors conclude that the rise induced in HDL-C by a high-fat, high-cholesterol diet is defensive and therefore, should not be interpreted as a desirable dietary change.
早期针对人类受试者的研究表明，低脂、低胆固醇饮食会降低血浆高密度脂蛋白胆固醇（HDL-C）以及载脂蛋白A-I（apo A-I）的生成率。最近对转基因小鼠的研究表明，高脂、高胆固醇饮食通过一种涉及调控apo A-I mRNA翻译的机制提高了血浆HDL-C和apo A-I的生成率。作者得出结论，高脂、高胆固醇饮食引起的HDL-C升高具有防御性，因此，不应将其解读为理想的饮食变化。
