美国西南部西班牙裔和非西班牙裔白人女性中单纯疱疹病毒、乙型肝炎和丙型肝炎抗体的血清流行率及危险因素

Seroprevalence of and risk factors for antibodies to herpes simplex viruses, hepatitis B, and hepatitis C among southwestern Hispanic and non-Hispanic white women.

作者信息

Becker T M, Lee F, Daling J R, Nahmias A J

机构信息

University of New Mexico School of Medicine, Albuquerque 87131-5306, USA.

出版信息

Sex Transm Dis. 1996 Mar-Apr;23(2):138-44. doi: 10.1097/00007435-199603000-00009.

DOI:10.1097/00007435-199603000-00009

PMID:8919741

Abstract

BACKGROUND AND OBJECTIVES

Few published data describe the seroprevalence of antibodies to herpes viruses and hepatitis viruses among Southwestern minority women.

GOALS

To determine the prevalence of antibodies to herpes simplex virus type-1 and type-2, hepatitis B, and hepatitis C among 595 southwestern Hispanic and non-Hispanic white patients seeking gynecologic care; and to investigate risk factors associated with seropositivity.

STUDY DESIGN

Analysis of serologic and interview data. Antibody assays were based on purified glycoprotein assays (herpes simplex virus), and commercial assays for hepatitis B virus and hepatitis C virus.

RESULTS

Hispanic ethnicity was a risk factor for herpes simplex virus type-1 (age-adjusted odds ratio, 3.1; 95% confidence interval, 1.8-5.3) but was not associated with antibodies to herpes simplex virus type-2, hepatitis B virus, or hepatitis C virus. Risks associated with seropositivity to herpes simplex virus type-2 included a high lifetime number of sex partners, history of any sexually transmitted disease, and increasing age. Among all patients with herpes simplex virus type-2 antibodies, only 11.1% gave histories of genital herpes infection. For women with antibodies to hepatitis B virus, 31.1% gave histories of hepatitis during adulthood.

CONCLUSIONS

The seroprevalence of antibodies to herpes simplex virus type-1 and herpes simplex virus type-2 was high in this clinic population; the prevalence of antibodies to herpes simplex virus type-1 was significantly higher in Hispanics than in non-Hispanic whites. Antibodies to herpes simplex virus type-2 and hepatitis B virus were associated with most indicator of sexual behavior. The high prevalence of antibodies to herpes simplex virus type-2 and the infrequent reporting of histories of genital herpes suggest that asymptomatic infection with herpes is common among these clinic patients.

摘要

背景与目的

鲜有已发表的数据描述西南地区少数民族女性中疱疹病毒和肝炎病毒抗体的血清流行率。

目标

确定595名寻求妇科护理的西南地区西班牙裔和非西班牙裔白人患者中单纯疱疹病毒1型和2型、乙型肝炎和丙型肝炎抗体的流行率；并调查与血清阳性相关的危险因素。

研究设计

血清学和访谈数据分析。抗体检测基于纯化糖蛋白检测（单纯疱疹病毒）以及乙型肝炎病毒和丙型肝炎病毒的商业检测。

结果

西班牙裔种族是单纯疱疹病毒1型的危险因素（年龄调整优势比，3.1；95%置信区间，1.8 - 5.3），但与单纯疱疹病毒2型、乙型肝炎病毒或丙型肝炎病毒抗体无关。与单纯疱疹病毒2型血清阳性相关的危险因素包括一生中有多个性伴侣、有任何性传播疾病史以及年龄增长。在所有单纯疱疹病毒2型抗体患者中，只有11.1%有生殖器疱疹感染史。对于乙型肝炎病毒抗体阳性的女性，31.1%在成年期有肝炎病史。