Pospísil Z, Krejcí J, Machatková M, Zendulková D, Lány P, Cíhal P
Department of Infectious Diseases and Veterinary Epidemiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Zentralbl Veterinarmed B. 1996 Mar;43(1):15-21. doi: 10.1111/j.1439-0450.1996.tb00283.x.
The effects of administration of an established, inactivated IBR vaccine were studied in 30 cows from two herds (one seropositive and one seronegative). All acquired immunity which, after subsequent intratracheal infection with IBR virus, prevented development of symptoms in the cows and protected their foetuses against viral infection in utero. The calves were all healthy and were born at normal term. Ten non-vaccinated cows from the seronegative herd responded to the experimental infection with mild respiratory disease and abortion of four out of 10 foetuses. Organs from the aborted foetuses were found to have IBR virus. In a breeding herd, without clinical signs of disease but with 40% of cows tested as seropositive, a 2-year disease-control programme was initiated. A total of 234 newborn calves were examined and it was shown that immunization of their dams with an inactivated vaccine conferred full in utero protection against IBR-virus infection. When such calves are reared in isolation they can be used as the nucleus for a seronegative breeding herd.
对来自两个牛群（一个血清阳性，一个血清阴性）的30头奶牛进行了一种已获认可的灭活传染性牛鼻气管炎（IBR）疫苗接种效果的研究。所有牛接种疫苗后获得了免疫力，随后经气管内感染IBR病毒时，可防止奶牛出现症状，并保护其胎儿在子宫内免受病毒感染。所有犊牛均健康且足月出生。来自血清阴性牛群的10头未接种疫苗的奶牛对实验性感染表现出轻度呼吸道疾病，10头胎儿中有4头流产。流产胎儿的器官中发现有IBR病毒。在一个无疾病临床症状但40%的奶牛检测为血清阳性的繁殖牛群中，启动了一项为期两年的疾病控制计划。共检查了234头新生犊牛，结果表明，用灭活疫苗对其母牛进行免疫可使其在子宫内获得完全保护，免受IBR病毒感染。当将这些犊牛隔离饲养时，它们可作为血清阴性繁殖牛群的核心。
