Pospísil Z, Krejcí J, Jínek P, Lány P, Zendulková D, Cíhal P
Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Vet Microbiol. 1996 Nov;53(1-2):199-206. doi: 10.1016/s0378-1135(96)01248-5.
Studies to investigate the efficacy of an inactivated vaccine against infectious bovine rhinotracheitis (IBR) suggest that this vaccine can prevent the in utero infection of calves from experimentally infected dams. In an experimental herd the inactivated vaccine induced a humoral immune response in both seropositive and seronegative cattle and, after subsequent intratracheal infection with IBR (BHV-1) virus, prevented development of symptoms in the cows and protected their fetuses against infection. The calves were all healthy and were born at term. The non-vaccinated, seronegative cows responded to the experimental infection with mild respiratory disease and abortion of 4 out of 10 fetuses. All organs from the aborted fetuses were found to have IBR virus. Through the use of this vaccine, the nucleus of a seronegative, virus-free breeding herd can be established. Thus, valuable genetic material can be preserved and the eradication of IBR becomes a realistic prospect. From our initially strictly controlled experiments producing 234 healthy calves, our programme was expanded into farm practice where 1001 calves were reared free from IBR virus.
旨在研究一种传染性牛鼻气管炎（IBR）灭活疫苗效力的多项研究表明，这种疫苗能够预防犊牛在子宫内被实验感染的母畜感染。在一个实验畜群中，该灭活疫苗在血清阳性和血清阴性的牛只中均诱导出了体液免疫反应，并且在随后用IBR（BHV-1）病毒进行气管内感染后，防止了母牛出现症状，并保护其胎儿免受感染。犊牛全部健康且足月出生。未接种疫苗的血清阴性母牛对实验感染的反应是出现轻度呼吸道疾病，并且10头胎儿中有4头流产。在流产胎儿的所有器官中均发现有IBR病毒。通过使用这种疫苗，可以建立一个血清阴性、无病毒的种畜核心群。因此，宝贵的遗传物质得以保存，IBR的根除也成为一个现实的前景。从我们最初严格控制的实验中产出了234头健康犊牛，我们的计划扩展到了农场实践，在那里饲养了1001头未感染IBR病毒的犊牛。
