聚（ε-己内酯）、聚（D，L-丙交酯）和聚（D，L-丙交酯-共-乙交酯）纳米颗粒的稳定性研究
Stability study of nanoparticles of poly(epsilon-caprolactone), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide).
作者信息
Lemoine D, Francois C, Kedzierewicz F, Preat V, Hoffman M, Maincent P
机构信息
Université catholique de Louvain, Unité de Pharmacie Galénique, Brussels, Belgium.
出版信息
Biomaterials. 1996 Nov;17(22):2191-7. doi: 10.1016/0142-9612(96)00049-x.
The objective was to evaluate the stability of nanoparticles prepared with poly(epsilon-caprolactone), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers and stored at different temperatures and in different media. The stability parameters studied were molecular weight and crystallinity of the polymer, nanoparticle size and pH. The results show that the stability of polymeric nanoparticles depends on (i) the type of polymers with the following increasing order of polymer stability: PLA25GA50 < PLA37.5GA25 < PLA50 = PCL, (ii) the storage temperature: PCL and PLA50 nanoparticles can be kept at 4 degrees C and RT during one year, while PLA37.5GA25 and PLA25GA50 nanoparticles have to be stored at 4 degrees C, and (iii) the storage conditions: buffering or freeze-drying nanoparticles improves stability.
目的是评估用聚（ε-己内酯）、聚（D，L-丙交酯）和聚（D，L-丙交酯-共-乙交酯）聚合物制备并在不同温度和不同介质中储存的纳米颗粒的稳定性。所研究的稳定性参数包括聚合物的分子量和结晶度、纳米颗粒大小及pH值。结果表明，聚合物纳米颗粒的稳定性取决于：（i）聚合物类型，聚合物稳定性的递增顺序如下：PLA25GA50 < PLA37.5GA25 < PLA50 = PCL；（ii）储存温度：PCL和PLA50纳米颗粒可在4℃和室温下保存一年，而PLA37.5GA25和PLA25GA50纳米颗粒必须储存在4℃；（iii）储存条件：缓冲或冻干纳米颗粒可提高稳定性。
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