Zemishlany Z, Aizenberg D, Weiner Z, Weizman A
Geha Psychiatric Hospital, Petah Tikva, Israel.
Int Clin Psychopharmacol. 1996 Sep;11(3):199-202. doi: 10.1097/00004850-199609000-00007.
Trihexyphenidyl (THP) and other anticholinergics are liable to abuse by schizophrenic patients. Data concerning the incidence and characteristics of the abusers are scarce. In the present study an evaluation of 214 consecutive admissions of schizophrenic patients revealed 14 THP abusers, an incidence of 6.5%. The demographic and clinical variables of the THP abusers were compared with a randomized control group of 28 schizophrenic patients using the four-dimensional factors of the BPRS (Brief Psychiatric Rating Scale). No significant differences were found in demographic variables and comorbidity for antisocial personality disorder and other substances abuse. On admission, a trend towards more negative symptoms was detected among abusers. At discharge abusers had significantly higher mean BPRS scores and higher scores on the dimensional factor of hostile-suspiciousness. The results suggest that THP abuse is not rare among schizophrenic patients who may abuse anticholinergic agents to relieve negative symptoms and/or drug-induced Parkinsonism, or alternatively for its non-specific stimulant effects, on account of worsening of positive symptoms.
苯海索（THP）及其他抗胆碱能药物容易被精神分裂症患者滥用。关于滥用者的发病率及特征的数据很少。在本研究中，对连续收治的214例精神分裂症患者进行评估，发现14例苯海索滥用者，发病率为6.5%。使用简明精神病评定量表（BPRS）的四维因子，将苯海索滥用者的人口统计学和临床变量与28例精神分裂症患者的随机对照组进行比较。在人口统计学变量以及反社会人格障碍和其他物质滥用的共病情况方面未发现显著差异。入院时，在滥用者中检测到有更多阴性症状的趋势。出院时，滥用者的BPRS平均得分显著更高，在敌对-猜疑维度因子上的得分也更高。结果表明，在精神分裂症患者中，苯海索滥用并不罕见，这些患者可能滥用抗胆碱能药物来缓解阴性症状和/或药物引起帕金森综合征，或者由于阳性症状恶化，为了其非特异性兴奋作用而滥用。
