Fisch R Z
Acta Psychiatr Scand. 1987 Jan;75(1):91-4. doi: 10.1111/j.1600-0447.1987.tb02757.x.
Trihexyphenidyl (THP) and other antiparkinsonian drugs are known to be substances of abuse. This is true both in abusers of other substances and in chronic schizophrenics, the latter being infrequent abusers of other drugs. Most reports on the abuse of antiparkinsonian drugs among schizophrenic patients warn against the possible harm of this self-medication. The present article describes the different effects of THP on both schizophrenic and non-schizophrenic abusers. The subjective experience in most chronic schizophrenic patients who abuse THP is positive: they claim that THP makes them feel and function better. In the light of these findings, the author suggests that research on the possible benefits of THP in contrast to the potential harm in chronic, residual schizophrenic patients is warranted.
已知苯海索（THP）及其他抗帕金森病药物是滥用物质。在其他物质滥用者以及慢性精神分裂症患者中均是如此，后者较少滥用其他药物。大多数关于精神分裂症患者滥用抗帕金森病药物的报告都警示了这种自我用药可能带来的危害。本文描述了THP对精神分裂症和非精神分裂症滥用者的不同影响。大多数滥用THP的慢性精神分裂症患者的主观体验是积极的：他们声称THP让他们感觉更好，功能状态更佳。鉴于这些发现，作者建议，有必要研究THP在慢性残留型精神分裂症患者中可能的益处及潜在危害。
