肝脏疾病中的血清糖蛋白。IV. 肝硬化患者的α-1酸性糖蛋白水平。

Serum glycoproteins in the liver diseases. IV. Alpha-1 acid glycoprotein level in liver cirrhosis.

作者信息

Arima T, Motoyama Y, Yamamoto T, Nagata K, Kondo T

出版信息

Gastroenterol Jpn. 1977;12(2):43-6. doi: 10.1007/BF02773624.

Abstract

Circulating alpha-1 acid glycoprotein level in cirrhotic patients was determined by radioimmunoassay, and was compared to the ones in normal subjects and chronic active hepatitis with sublobular necrosis. Serum alpha-1 acid glycoprotein levels in liver cirrhosis (p less than 0.001) and chronic active hepatitis with sublobular necrosis (p less than 0.02) were significantly reduced comparing to the normal subjects, although any statistically significant difference was not observed between the formers. In liver cirrhosis, thie serum alpha-1 acid glycoprotein level correlated negatively with serum albumin concentration but neither with serum alpha-1 globulin fraction nor with Indocyanine green clearance rate.

摘要

采用放射免疫分析法测定肝硬化患者循环中α-1酸性糖蛋白水平，并与正常受试者及伴有小叶下坏死的慢性活动性肝炎患者进行比较。与正常受试者相比，肝硬化患者（p<0.001）及伴有小叶下坏死的慢性活动性肝炎患者（p<0.02）的血清α-1酸性糖蛋白水平显著降低，尽管两者之间未观察到统计学上的显著差异。在肝硬化患者中，血清α-1酸性糖蛋白水平与血清白蛋白浓度呈负相关，但与血清α-1球蛋白组分及吲哚菁绿清除率均无相关性。