Ozeki T, Okada Y, Iwaki K
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Gastroenterol Jpn. 1987 Aug;22(4):448-52. doi: 10.1007/BF02773812.
The level of serum orosomucoid, the amount of sialic acid binding to it, and the binding rate of sialic acid to orosomucoid in normal individuals and in patients with chronic hepatitis and liver cirrhosis were determined by affinity column chromatography, SDS electrophoresis and the method of Warren. Although no apparent changes in the level of serum orosomucoid or the amount of sialic acid binding to it in each group were seen, the binding rate of sialic acid to orosomucoid in chronic persistent hepatitis and chronic active hepatitis showed a remarkable increase, compared with normal individuals and patients with liver cirrhosis. Furthermore, the binding rate of sialic acid in liver cirrhosis was the lowest in each group.
采用亲和柱色谱法、SDS电泳法及沃伦法，测定了正常个体、慢性肝炎患者和肝硬化患者血清类粘蛋白水平、与其结合的唾液酸量以及唾液酸与类粘蛋白的结合率。虽然每组血清类粘蛋白水平或与其结合的唾液酸量均未见明显变化，但与正常个体及肝硬化患者相比，慢性持续性肝炎和慢性活动性肝炎患者唾液酸与类粘蛋白的结合率显著升高。此外，肝硬化患者唾液酸的结合率在各组中最低。
