肝脏疾病中的血清糖蛋白。II. α1酸性糖蛋白的放射免疫测定
Serum glycoproteins in the liver diseases. II. Radioimmunoassay of alpha-1 acid glycoprotein.
作者信息
Arima T, Motoyama Y, Nagata K, Kondo T
出版信息
Gastroenterol Jpn. 1976;11(4):307-12.
A radioimmunoassay for human alpha1-acid glycoprotein has been developed. 97.8% of 125I-alpha1-acid glycoprotein prepared for the assay were immunoprecipitable with specific anti-sera against the protein. alpha1-acid glycoprotein concentration in sera from normal adults was found to range between 70 and 114 mg/100 ml, with a mean of 93. Fulminant hepatitis, liver cirrhosis or chronic active hepatitis with sublobular necrosis caused a significant lowering of alpha1-acid glycoprotein concentration. Sera obtained from patients with acute hepatitis in convalescence, chronic inactive hepatitis or primary biliary cirrhosis gave normal concentration of the glycoprotein.
已开发出一种用于检测人α1-酸性糖蛋白的放射免疫分析方法。用于该分析的125I-α1-酸性糖蛋白中，97.8%可被针对该蛋白的特异性抗血清免疫沉淀。发现正常成年人血清中α1-酸性糖蛋白浓度在70至114毫克/100毫升之间，平均为93毫克/100毫升。暴发性肝炎、肝硬化或伴有亚小叶坏死的慢性活动性肝炎会导致α1-酸性糖蛋白浓度显著降低。从急性肝炎恢复期患者、慢性非活动性肝炎患者或原发性胆汁性肝硬化患者获得的血清中，该糖蛋白浓度正常。
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