Chia S E, Chia K S, Chia H P, Ong C N, Jeyaratnam J
Department of Community, Occupational & Family Medicine, National University of Singapore, Republic of Singapore.
Scand J Work Environ Health. 1996 Oct;22(5):374-80. doi: 10.5271/sjweh.157.
The purpose of this study was to investigate the serial nerve conduction parameters of a group of lead-exposed workers and determine their correlation with the serial blood lead results over a three-year period. A "nonresponse" level (defined as no significant changes in the nerve conduction in response to changes in the blood lead level of each exposed worker observed over the period of study) was also determined for blood lead in respect to the peripheral nerves.
Seventy-two male workers from a lead battery manufacturing factory were followed at six-month intervals for three years. At each follow-up, the blood lead level was determined and nerve conduction tests (ulnar and median nerves) were conducted. A group of 82 unexposed subjects served as referents.
Significant differences were observed for some of the mean values of the median nerve conduction parameters between the exposed and reference groups. The 28 exposed workers who completed the follow-up were divided into the following two blood lead categories: < 40 micrograms. 100 ml-1 (< 1.93 micromol.l-1 and > or = 40 micrograms. 100 ml-1 (> or = 1.93 micromol.l-1. In the latter, the median motor conduction velocity, median distal latency, median amplitude, ulnar motor conduction velocity, and ulnar amplitude were significantly correlated (adjusted for age and within-subject variation) with the blood lead levels, but not so in the former.
According to the three-year serial results, the "nonresponse" level for blood lead with respect to the peripheral nerves would be < 40 micrograms.100 ml-1 (< 1.93 micromol. l-1).
本研究旨在调查一组铅暴露工人的系列神经传导参数，并确定其在三年期间与系列血铅结果的相关性。还针对外周神经确定了血铅的“无反应”水平（定义为在研究期间观察到的每个暴露工人的血铅水平变化时神经传导无显著变化）。
对一家铅酸蓄电池制造工厂的72名男性工人进行了为期三年的随访，每隔六个月进行一次。每次随访时，测定血铅水平并进行神经传导测试（尺神经和正中神经）。一组82名未暴露的受试者作为对照。
暴露组和对照组之间正中神经传导参数的一些平均值存在显著差异。完成随访的28名暴露工人被分为以下两类血铅水平：<40微克/100毫升（<1.93微摩尔/升）和≥40微克/100毫升（≥1.93微摩尔/升）。在后者中，正中运动传导速度、正中远端潜伏期、正中波幅、尺神经运动传导速度和尺神经波幅与血铅水平显著相关（经年龄和个体内变异校正），而在前者中则不然。
根据三年的系列结果，外周神经血铅的“无反应”水平为<40微克/100毫升（<1.93微摩尔/升）。
