Zhirnov O P, Kirzhner L S, Ovcharenko A V, Malyshev N A
Vestn Ross Akad Med Nauk. 1996(5):26-31.
Aprotinin aerosol has been previously shown to have protective effects in experimental influenza- and parainfluenza-induced bronchopneumonias in animals. This paper presents the results of controlled clinical studies to evaluate the therapeutical efficiency of aprotinin aerosol in natural influenza and parainfluenza infections in human beings. A total of 52 patients were followed up. They received either soda (placebo) or aprotinin inhalations thrice a day for 4-5 days. The following mean duration (in days) of symptoms was found in the control (placebo-treated) and aprotinin-treated patients. These were: 2.5 versus 1.8 for fever, 2.0 versus 1.5 for headache, 2.9 versus 1.8 for weakness, 3.9 and 2.8 for common cold, 3.1 versus 1.6 for sore throat, 4.9 versus 2.8 for pharyngeal hyperemia, 4.9 versus 4.0 for cough, and 3.5 versus 1.3 for hoarse voice (p < 0.05). Inhaled aprotinin was well tolerated by the patients and caused no topical irritating effects and allergic reactions. The findings demonstrate the noticeable clinical efficacy of aprotinin aerosol in human influenza and parainfluenza.
抑肽酶气雾剂先前已被证明在实验性流感和副流感诱发的动物支气管肺炎中具有保护作用。本文介绍了对照临床研究的结果，以评估抑肽酶气雾剂对人类自然感染流感和副流感的治疗效果。共对52例患者进行了随访。他们每天接受三次苏打水（安慰剂）或抑肽酶吸入治疗，持续4 - 5天。在对照组（接受安慰剂治疗）和接受抑肽酶治疗的患者中发现了以下症状的平均持续时间（以天为单位）。这些症状的持续时间分别为：发热2.5天对1.8天，头痛2.0天对1.5天，虚弱2.9天对1.8天，普通感冒3.9天和2.8天，喉咙痛3.1天对1.6天，咽充血4.9天对2.8天，咳嗽4.9天对4.0天，声音嘶哑3.5天对1.3天（p < 0.05）。患者对吸入的抑肽酶耐受性良好，未引起局部刺激作用和过敏反应。这些发现证明了抑肽酶气雾剂对人类流感和副流感具有显著的临床疗效。
