Skibitskiĭ V V, Galenko-Iaroshevskiĭ P A, Kanorskiĭ S G, Khankoeva A I, Bartashevich V V, Uvarov A V
Vestn Ross Akad Med Nauk. 1996(5):9-12.
A hundred and twenty two patients with premature ventricular contractions and paroxysmal tachycardias were comprehensively studied prior to and following treatment regimen with ethacizin, befol, sodium succinate and their combinations. Besides its significant antiarrhythmic activity, ethacizin displayed a number of adverse cardiac effects, such as excessive negative inotropic and dromotropic ones. Befol and sodium succinate in combination with ethacizin can reduce or even eliminate these side effects in rest and during simulated mental stress and graded exercise. The antiarrhythmic effect of the combined therapy preserved or even became stronger. This therapy may be long performed for arrhythmias even in patients with circulatory insufficiency and cardiac conduction disturbances caused or redoubled by ethacizin.
对122例室性早搏和阵发性心动过速患者在使用乙胺碘呋酮、倍他乐克、琥珀酸钠及其联合用药治疗方案前后进行了全面研究。乙胺碘呋酮除具有显著的抗心律失常活性外，还表现出一些不良心脏效应，如过度的负性肌力和负性传导作用。倍他乐克和琥珀酸钠与乙胺碘呋酮联合使用可在休息时以及模拟精神应激和分级运动期间减少甚至消除这些副作用。联合治疗的抗心律失常作用得以保留甚至增强。即使在因乙胺碘呋酮引起或加重循环功能不全和心脏传导障碍的患者中，这种治疗方法也可长期用于心律失常。
